Many DNA-binding factors recognise specific sequences of nucleotides (sequence motifs), which are frequently displayed as so-called position weight matrices (PWM). We are using computational approaches to find sequence motifs in short genomic intervals that show features of regulatory sequences (like transcription initiation, DNase hypersensitivity, transcription factor binding or the presence of particular epigenetic marks). This can be a powerful way to identify regulators that control cell type-specificity or cellular responses.
Michael Rehli • Dept. Internal Medicine III • University Hospital
F.-J.-Strauss Allee 11 • 93053 Regensburg • Germany
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