Michael Rehli • Dept. Internal Medicine III • University Hospital • F.-J.-Strauss Allee 11 • 93053 Regensburg
Epigenetics & Gene Regulation
Although every cell in the human body shares an identical genome, most genes are only activated in certain cell types, at specific developmental stages, or upon stimulation. To organize and manage genetic information and to enable cellular specification, nature has evolved sophisticated mechanisms that facilitate the tightly controlled, accurate activation of genes.
Our laboratory is interested in the processes that orchestrate cell type-specific gene regulation during cellular differentiation. We study the interplay between transcription factors and epigenetic mechanisms (in particular DNA methylation) in regulating hematopoietic lineage specification and leukemia development. We also investigate mechanisms controlling the active setting and removal of DNA methylation, a major epigenetic mechanism associated with gene silencing.