Mononuclear Phagocyte Biology
Epigenetics of Cell Differentiation

Our Research

Our lab is mainly interested in mechanisms and interplay of transcription, epigenetics, and chromatin structure as well as their impact on cell biology in health and disease.

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Transcription Factors

Using combinations of genome-wide assays and biochemistry to study how transcription factors select their binding sites in the context of nuclear chromatin.

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Epigenetics & Differentiation  

Studying the establishiment & function of epigenetic marks in normal myeloid development and leukemia using genome-wide technologies and functional approaches.

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Genome Structure

Understanding the role of cohesin and its mutations in hematopoiesis & leukemia using advanced genome-wide approaches to map the genome in three dimensions.

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Cell Therapy

Leveraging genome-wide technologies and bioinformatics analysis to understand transcriptional networks controlling the therapeutic efficacy of regulatory T cells.

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Metastasis

Applying mouse models and genetic engineering to understand the impact of DNA methylation on metastatic progression.

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Epigenetic Variation

Using genetic and epigentic screens to identify mechanisms behind interindividual epigenetic variation.


Networks

With our expertise in NGS technologies and data analysis, we are involved in various collaborative efforts and consortia on cancer, immunology and epigenetics.



Funding

Without the funding from the following agencies and foundations, our research would not be possible!

Deutsche Forschungsgemeinschaft


Deutsche Krebshilfe

Else-Kröner-Fresenius-Stiftung
Rudolf-Bartling-Stiftung


Michael Rehli • Dept. Internal Medicine III • University Hospital
F.-J.-Strauss Allee 11 • 93053 Regensburg • Germany

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