Michael Rehli • Dept. Internal Medicine III • University Hospital • F.-J.-Strauss Allee 11 • 93053 Regensburg
Interindividual Epigenetic Variability
Epigenetic processes are fundamental to the differentiation and development of multicellular organisms by controlling chromatin accessibility and transcription. Although phenotypic variation is mainly driven by genetic traits, there is evidence that epigenetic mechanisms may contribute to inter-individual phenotypic differences in mammals. But the exact processes leading to inter-individual epigenetic differences are largely obscure. Besides being triggered by environmental influences, epigenetic differences between individuals may also be inherited; however, the relationship between epigenetic traits and inter-individual genetic differences is often unclear.